NEUROSCIENCE RELATED PROJECTS
Modeling cerebral reperfusion injury using photoacoustic microscopy and oxygen-sensing nanoparticles
This project explores a novel non-invasive, dynamic imaging approach capable of quantifying functional changes in the brain following reperfusion after stroke.
A systems approach to understanding a neuronal circuit for detecting motion
Fruit fly larvae develop a simple learned visual recognition system to determine membership in cooperative feeding groups and we propose to study the underlying neural circuit.
Genetically-Encoded Norepinephrine Sensors
Norepinephrine (NE) ubiquitously mediates cell-to-cell communication, yet NE transmission remains poorly understood. We aim to develop NE sensors to transform NE biological and translational research.
Effects of perturbation of mRNA export pathways on neuron function
This project will explore the effect of CRISPR/Cas9 mediated mutations in the NXF1 gene on the outgrowth and function of primary hippocampal and cortical neurons in culture systems.
Brain Synchrony During Student-Teacher Interactions
Real-world interactions involve multiple brains engaging together. Traditional neural metrics consider individuals in isolation. We will quantify engagement via student-teacher brain synchrony.
Automatic Sensing and Characterization of Social Interactions
The objective of this project is to design technology to measure the presence of and quality of social interactions.
Harnessing the Wandering Mind
How can you harness a wandering mind or control creativity? Our answers combine cognitive neuroscience, Western, and Buddhist philosophy to illuminate "meta-actions" relevant to ADHD and depression.
Generation and characterization of a preclinical models to study DDX3X disorder
DDX3X mutation cause intellectual disabilities, seizures, autism, poor muscle tone, and slower physical developments. We propose to generate a female mouse model carrying germline DDX3X mutations.
Comparing and Contrasting Artificial Neural Networks with Biological Neural Networks for Improved Representation Learning
We will study what are the implications of the different modes of operation of artificial neural networks and biological neural networks, and how do they build abstraction into their representations.
Role of innate immunity in impaired neurodevelopment during zika virus infection
We will study neuroprogenitors by intraventricular injection of ZIKV into fetus of pregnant mice. We will assess the inflammatory signaling with high-throughput protein kinase/phosphatase assay.
Single cell proteomics of the hypothalamus
Using mass cytometry (CyTOF), this project will identify unique mammalian hypothalamic cell types important for energy homeostasis.
Genetic Dissection of Vagal Motor Circuits Controlling Heart Function
Our project will define the synaptic circuitry and functional role of three novel neuron types in the nucleus ambiguous, the major parasympathetic input to the cardiovascular and respiratory systems.
Building an in vitro model for Neural Tube Defects
Establish an in vitro model to study formation and function of the nervous system in the pathological conditions of Neural Tube Defects.
Neuromuscular pedicle for improved functional outcome of novel muscle regeneration scaffolds
We aim to generate clinical functional recovery after volumetric muscle loss by combining a neuromuscular pedicle embedded into novel scaffolds to provide regenerative cells and paracrine signaling.